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Fig. 7. Downregulation of Otx1 expression. In wild-type mice, Otx1 transcripts were detected by in situ hybridization in the developing ciliary and iris epithelia at E18 (A), P1 (B) and P7 (C). In CPV2-Noggin transgenic mice, no significant change in expression was observed in E18 eyes (D), but Otx1 appeared to be switched off (arrowheads) in the presumptive ciliary epithelium of P1 (E) and P7 (F) eyes. Levels of Otx1 transcripts remained essentially unchanged in the iris of transgenic mice. Scale bars: 100 µm.





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