Fig. 7. Model for the role of LET-99 in nuclear rotation and anaphase spindle positioning in one-cell embryos. Anterior is towards the left. Centrosomes and microtubules are shown in green. Yellow arrows indicate forces from the cortex acting on subsets of astral microtubules. Broken lines indicate microtubules that contact regions enriched for LET-99 and experience less force (small yellow arrows; see text). Red arrows indicate the net force acting on the centrosomes or spindle poles, with size proportional to the magnitude of the force. (A) Prediction of forces during centration/nuclear rotation and anaphase spindle positioning in wild type. (B) Prediction of forces on spindle poles during anaphase in par-3 mutant embryos.

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