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Fig. 5. mRNA in situ hybridization for two neural crest markers CrabP1 and Ap2{alpha} revealed a similar NCCs stream between wild type and Fgf8 mutants for second and third PA (arrows in A,B) and first and second PA (arrows in C,D). Lineage trace of NCCs using the transgenic lines P0-Cre and R26R (E,F) (see Materials and Methods) demonstrated decreased NCCs within the PAs. High-powered examination of the outflow tract (red brackets in E,F) also demonstrated that decreased NCCs were entering the outflow tract of Fgf8 mutants (arrowheads, H) when compared with controls (arrowheads, G), despite NCCs having progressed as far into the outflow tract (arrows in G,H). G and H are at the same magnification and embryos had the same number of somites (±2).





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