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Fig. 3. Expression of pituitary hormone genes is affected in Pitx2 hypomorphs. In situ hybridization using pituitary cell-specific markers was performed in Pitx2neo homozygotes and wild-type littermates at P1. The expression of gonadotrope-specific markers Lhb (A,B), Fshb (C,D) and Gnrhr (E,F) is almost undetectable in Pitx2neo/neo pituitaries. Gh (G,H), Ghrhr (I,J) and Tshb (K,L) in situ hybridization reveals the reduction in somatotropes and thyrotropes, respectively. POMC-producing corticotropes appear to develop normally in Pitx2neo/neo mice (M,N).





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