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Fig. 6. Pitx1 and Pix2 have functional overlaps in pituitary ontogeny. Histological examinations of double mutants carrying Pitx1– and Pitx2neo alleles show the normal formation of Rathke’s pouch in all genotypes (A-C), but not in Pitx1–/–;Pitx2neo/neo mice at E12.5 (D). Note that Rathke’s pouch in Pitx1–/–;Pitx2neo/neo mice does not expand (D). Immunoreactive LHX3 is present all genotypes (E-H).





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