Fig. 1. Expression of teneurin 2 in the visual system. (A) Anti-teneurin 2 labels the inner plexiform layer (IPL) and optic fiber layer (OFL) of the E11 retina. (B) The staining in the OFL extends through the optic nerve head and into the optic nerve (ON). (C) At E12 anti-teneurin 2 labels the IPL and OFL, with distinctive laminae being labeled in the former. (D) An adjacent section subjected to in situ hybridization with a teneurin 2 cRNA probe reveals teneurin 2 transcripts concentrated in the retinal ganglion cell layer (GCL). Nearby sections treated with a sense control probe were unlabeled (not shown). (E) The stratum opticum (SO) of the optic tectum is stained with anti-teneurin 2 at E11. (F) The deepest layer of the optic tectum, the stratum griseum periventriculare (SGP), is also labeled with anti-teneurin 2 at E11.

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