spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 4. Gli2, but not Gli1, is required for Shh signaling in Ptc mutants. X-gal staining of Ptc-lacZ in six- to eight-somite E8.5 embryos. In wild-type embryos, Ptc-lacZ is expressed in the ventral CNS and somites (A). The expression of Ptc-lacZ is not altered in Gli1zfd/zfd;Ptc+/– embryos (B), but the expression is downregulated in Gli2zfd/zfd;Ptc+/– embryos (C). Loss of Ptc function results in upregulation of Ptc-lacZ throughout the embryos (D). Removal of Gli1 function in Ptc–/– embryos does not rescue the overexpression of Ptc-lacZ (E). However, removal of Gli2 function in Ptc–/– embryos (F) reduces the overexpression of Ptc-lacZ in the head (arrow) and the trunk mesoderm (arrowhead). Scale bar: 0.5 mm.





Right arrow Return to article