Fig. 3. Lmo4 is expressed in trkC-positive proprioceptive sensory neurons in muscle-pool-specific patterns. Lmo4 expression in nuclei of DRG sensory afferents was detected with an Lmo4-specific antibody (red in all panels). At stage 35, trkC- and trkA-specific antibodies stain (green) cytoplasm of large-diameter trkC-positive proprioceptive sensory neurons located ventrolaterally (upper right-hand corner in A) and small-diameter trkA-positive cutaneous sensory neurons located dorsomedially (lower left-hand corner in B) in the DRG, respectively. Most (83%) trkC-positive sensory neurons are Lmo4 positive, whereas almost none of the trkA-positive sensory neurons express Lmo4. (C-G) Lmo4 expression in sensory neurons supplying individual muscles was determined by retrograde labeling with green fluorescent dye at stage 39. Lmo4 is expressed in most adductor (79%, D) and external femorotibialis (73%, E) sensory neurons, but few sartorius sensory neurons are Lmo4-positive (13%, C) (one Lmo4-positive cell is indicated with arrow). Sensory neurons supplying the internal femorotibialis (F) and posterior iliotibialis (G) muscles are Lmo4 negative. Scale bar: 150 µm.

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