Fig. 3. Notch signaling is compromised in the absence of Mash1 function as early as E10.5. Dark-field photomicroscopic images of coronal hemi-sections of control (left side) and Mash1 mutant (right side) telencephalons at E10.5 (A-F') and E11.5 (G-I') studied using ³⁵S-labeled radioactive in situ hybridization. The cDNAs encoding the riboprobes used in the analysis are listed above each normal/mutant pair of images. The VZ in the Mash1 mutant has molecular characteristics of the SVZ, based on the increased expression of Dlx5, Gad67 and the reduced expression of Hes5 (arrowheads in G-I'). ctx, cortex; LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence; VZ, ventricular zone. Scale bar: 100 µm.

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