Fig. 5. Germline CSN5 mutations affect follicle cell patterning. (A-D) Reduction of CSN5 function disrupts the specification of the terminal follicle cells. In wild-type egg chambers, the PZ6356 enhancer trap is expressed in border cell and oocyte nuclei (A), while the slbo enhancer trap is expressed only in border cells (C). In CSN5 mutant egg chambers, both enhancer traps are also expressed in posterior follicle cells (arrows, B,D), suggesting that they have taken on anterior fate. (E-H) CSN5 GLCs affect patterning of the dorsoanterior follicle cells. In CSN5-mutant egg chambers, expression of the kekkon enhancer trap is often reduced (F,G) or in rare cases undetectable (not shown). In a small number of egg chambers, kekkon is expressed in a larger than normal patch of dorsal follicle cells (H).

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