Fig. 3. Pitx2c in remodeling the great vessels and outflow tract. (A) Remodeling of aortic arch arteries and derivation of mature aortic arch vessels (adapted from Moore, 1982). (B-D) Corrosion cast of wild-type (B) and Pitx2 c^-/- embryos with correct direction of aortic arch (C) and reversed orientation (D). (E-G) Corrosion cast of a Pitx2 c^-/- embryo with double aortic arch showing ventral (E), ventral oblique (F) and dorsal (G) views. (H-J) Diagrams of the corrosion cast to more clearly show changes in vessel morphology. Each diagram is associated with the cast directly above. (K-N) India ink injection into wild-type and Pitx2 c^-/- embryos at 11.5 dpc. Right and left oblique views are shown. (O,P) Casting dye injection into 18.5 dpc wild-type and Pitx2 c^-/- embryos showing DORV in mutant (P). ao, aorta; baa, branchial arch arteries; cc, common carotid; d, ductus arteriosus; in, innominate artery; lcc, left common carotid; lpa, left pulmonary artery; lsa, left subclavian artery; pa, pulmonary artery; pt, pulmonary trunk; rcc, right common carotid artery; rpa, right pulmonary artery; rsa, right subclavian artery; s, subclavian artery.

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