Fig. 4. Fate mapping with Wnt1 cre transgenic and the Rosa26 reporter. (A,B) Ventral view of whole-mount lacZ staining of 12.5 dpc wild-type and Pitx2 c^-/- mutant embryo. (C-F) Rostral (C,D) and caudal (E,F) transverse section through the conotruncus of lacZ stained embryos showing lacZ-labeled cardiac crest derivatives contributing to valves and cushions of OFT (denoted by arrows). (G-J) Parsagittal sections through 10.5 dpc wild-type (G,I) and Pitx2 c^-/- (H,J) mutant embryos at different mediolateral planes of section. Branchial arch arteries are numbered. ao, aorta; pt, pulmonary trunk.

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