Fig. 1. Structure of Xror2 and its mutant constructs. (A) Comparison of predicted amino acid sequences of Xror2 and mouse Ror2 and Ror1. X_ror2, Xror2 accession no. AB087137; M_Ror2, mouse Ror2 (NM013846); M_Ror1, mouse Ror1 (NM013845). The domain structure of the Ror family is indicated by overlines with the domain names. Conserved residues shared by all or by two of them are in black or shaded boxes, respectively. Asterisks, conserved cysteines in the Frizzled-like domain; dashes, spaces for alignment; dots, predicted ATP-binding motifs. (B) Schematic diagrams of Xror2 constructs. SP, signal peptide; IG, immunoglobulin-like domain; FZ, Frizzled-like domain; KR, kringle domain; TM, transmembrane domain; TK, tyrosine kinase domain. See text for details.

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