Fig. 4. DV and ML patterning in the inner ear. (A-D) Expression of otx1 at 24 h in wild-type (A,C) and val/val (B,D) embryos. Dorsal views (A,B) show expression in the lateral epithelium of the otic vesicle (arrowheads) and lateral views (C,D) show expression in the ventral epithelium. (E,F) Dorsolateral views showing expression of dlx3 at 24 h in wild-type (E) and val/val (F) embryos. Gene expression patterns are normal. (G-I) Lateral views of the inner ear at 72 h in wild-type (G) and val/val (H,I) embryos. Morphology ranges from nearly normal to highly aberrant. Anterior is towards the left in all specimens. Abbreviations: a, anterior semicircular canal; 1, lateral semicircular canal; p, posterior semicircular canal; u, utricle. Scale bar: 100 µm in A,B,G-I; 50 µm in C-F.

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