Fig. 3. Conditional removal of Shh activity from the urothelium with HoxB7/Cre results in hypoplasia, hydroureter and hydronephrosis. (A,B) Whole-mount view of the newborn kidney and ureter of wild-type (WT) and HoxB7/Cre, Shh^c/n mice. (C-J) Hematoxylin and Eosin staining of coronal sections (C,D) and parasagittal sections (G,H) of the kidney (C,D,G,H) and cross-sections of the ureter (E,F,I,J) at stages indicated. Scale bars: 500 µm in C,D; 100 µm in E,F,I,J; 1 mm in G,H.

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