Fig. 1. Activation of the Wingless signalling pathway blocks eye differentiation. (A-C) Scanning EM images of adult eyes with axin^- clones. axin mutant cells induce the differentiation of frons cuticle corresponding to the dorsal head (arrowhead in B), but also naked cuticle (arrow in B). (C) Large axin mutant clone causing a tube-like overgrowth with multiple macrochaetae (arrow). (D-G) In third instar eye discs, axin mutant clones (which lack red anti-lacZ staining) occasionally express Distal-less (green); anterior towards the left. The expression of Distal-less is associated with tube-like overgrowth. These overgrowths appear in a different focal plane that can be seen in transverse sections of the disc (E-G; the positions of the sections are indicated by the white lines in D).

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