Fig. 1. (A,B) Comparison of the spider Delta and Notch structures to the Drosophila proteins and alignment of the DSL domain. (A) The Drosophila Notch protein contains several conserved domains. The sequence obtained so far for Notch encodes two different transcripts. One transcript lacks part of EGF repeat 6 and specifically EGF repeats 7, 8 and 9. (B) CsDelta1 shares the highly conserved DSL domain (Delta, Serrate, Lag2) and eight EGF repeats with the fly sequence. CsDelta2 contains the conserved DSL domain, but has only five EGF repeats. Both spider Delta proteins have a shorter intracellular domain. (C) The DSL domains of both CsDelta1 and CsDelta2 show a higher identity to the same region of the Xenopus X-Delta1 protein (66% and 62% identity, respectively) than to Drosophila (62% and 57% identity, respectively). Ank, ankyrin repeat; DSL, Delta, Serrate, Lag2 domain; EGF-rep, EGF repeats; N/lin12, Notch lin12 repeats; Pest, a region rich in proline, glutamine, serine and threonine residues; RAM, RAM23 domain.

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