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Fig. 5. AChR subunit genes are transcribed selectively in subsynaptic nuclei of Musk mutant mice expressing MCK-Musk and MCK-MMT. AChR {alpha} and {delta} mRNAs are expressed preferentially in the central, synaptic region of muscle (arrows) in wild-type mice and uniformly in skeletal muscle of Musk-/- mice. In Musk-/-; MCK-Musk and Musk-/-; MCK-MMT mice, AChR {alpha} and {delta} mRNAs are expressed preferentially in the central region of the muscle. The pattern of AChR transcription was assessed by in situ hybridization of intercostal muscle from E18.5 embryos.





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