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Fig. 2. Expression and activity of ephrin-A ligands in the E10 cerebellum. (A-F)
RNA in situ hybridization (A,B,D,E) and affinity probe in situ (C,F) of whole
mount cerebellum. Capital letters indicate domain names. (A-C) Dorsal is at
the top. (D-F) Anterior is at the top. Expression of ephrin-A2 is
strongest in domain C (lobules I-IXab), followed by domain A (lobules I-VIII)
and E (lobules II-VII). ephrin-A5 is moderately expressed in domains
A (lobules I-V), C (lobules I-V), D (lobules I-VIII) and F (lobules III-VIII).
Total ligand activity detected with an EphA3-AP probe corresponds to the RNA
expression patterns. (G) ephrin-A2 expression in a coronal section of
the cerebellum (lobulus VII). Parasagittal pattern is seen in the Purkinje
cell layer (pl). Asterisk, deep cerebellar nuclei. (H) A diagram of
parasagittal domains in the cerebellum. Please note that expression patterns
of ephrin-A2 and ephrin-A5 are shown only in domains A-C.
Scale bars: 500 µm.
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