Fig. 7. Model for Hyd function. Arrows represent positive effects, and barred lines represent negative effects. Hyd represses hh transcription, probably indirectly. Hyd also blocks the accumulation of full-length Ci without affecting Smo. Since Slmb has been implicated in processing Ci to the repressor form Ci₇₅, we suggest that Hyd may instead act by targeting Ci for degradation.

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