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Fig. 6. Neural tube closure requires Xdsh function in the midline. (A) Targeted injection into dorsal medial animal blastomeres at the 16-cell stage. (B) Targeted injection into the dorsal lateral animal blastomeres. (C) GFP lineage tracing of medial injection at stage 14 reveals delivery to midline. (D) GFP lineage tracing of lateral injection at stage 14 reveals delivery to lateral neural plate. (E) Medial injection results in NT closure defects, and GFP labels floor of open NT (e'). (F) Lateral injection does not elicit NT closure defects and GFP labels dorsal NT and epidermis (f').





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