Fig. 2. Human hand-foot-genital (HFG) and chick HFGa13 overexpressed embryos have similar limb phenotypes. (A-D) Control (left panel) and HFGa13-infected (right panel) hindlimbs at E6. Planar sections of E6 limbs (B), uninjected control (left) HFGa13-infected hindlimb [right, arrows indicate fibula maldevelopment (fibula*) with undifferentiated mesenchymal cells]. (C) In situ hybridization of Fgf8 in sectioned hindlimb. No Fgf8 expression is detected in the HFGa13-infected hindlimb compared with the uninfected hindlimb (arrows). (D) In situ hybridization of Bapx1 in sectioned hindlimb. There is altered Bapx1 expression in the HFGa13-infected hindlimb (arrows).
