Fig. 7. Expression of Slits is altered in the forebrain of Nkx2-1 mutants. Serial coronal sections through the telencephalon (A,B,E,F) and diencephalon, and caudal telencephalon (C,D,G,H) of E13.5 wild-type (A-D) and Nkx2-1 (E-H) mutant embryos showing the expression of Slit1 (A,C,E,G) and Slit2 (B,D,F,H). Dorsal is upwards and the midline is to the right in all panels. Arrowheads point to regions of increased Slit1 expression, whereas arrows denote regions where Slit2 expression is either lost or decreased. AEP, anterior entopeduncular region; DT, dorsal thalamus; GP, globus pallidus; H, hippocampus; Hyp, hypothalamus; Hyp*, mutant hypothalamus; LGE, lateral ganglionic eminence; LGE*, mutant lateral ganglionic eminence; MGE, medial ganglionic eminence; NCx, neocortex; POa, preoptic area; POa*, mutant preoptic area; Str, striatum; Str*, mutant striatum. Scale bar: 500 µm.
