Fig. 2. Abnormal development of CA1 region of hippocampus in Dab1^p45/– hemizygotes. (A,A’) Dab1^p45/–, (B,B’) Dab1^p45/+, (C) Dab1^p45/p45, (D) Dab1^5F/5F, (E) Dab1^+/– and (F) Dab1^p45/p45Reln^–/+ brains were sectioned and stained with Nissl. Animals A-C were littermates, and all brains were harvested at P20. The arrow indicates ectopic pyramidal cell layer, squares mark the alveus and circles mark the hippocampal fissure. These provide landmarks for the inner (ventricular) and outer (pial) surface of the hippocampus. Abbreviations: 1, CA1 region; 2, CA2 region; 3, CA3 region; DG, dentate gyrus. Scale bar: 400 µm in A-F; 25 µm in A’,B’.

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