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Fig. 5. Heart defects in J1N2+/– mice. (A-D) Transverse sections of (A,C) wild-type and (B,D) J1N2+/– hearts at E16.5. (B) Heart with an atrial septal defect (arrow); (D) heart with a ventricular septal defect (arrow). (E,F) Frontal sections of wild-type (E) and J1N2+/– (F) hearts at E15.5. The mutant (F) has a hypoplastic right ventricle and an overriding aorta. ra, right atrium; la, left atrium; ao, aorta; rv, right ventricle; lv, left ventricle.





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