Fig. 6. Fasiculation of both dorsal and ventral nerve cords depends on vab-7 activity. (A-E) unc-17/cha-1::gfp was used to visualize cholinergic motoneurone processes in adults. (A) Ventral view of wild type. Arrows point to normal right and left process bundles in the VNC. (B) Ventral view of vab-7(e1562) showing highly defasciculated VNC (arrows). (C) Dorsal view of wild type. Arrowhead points to the DNC; arrows point to dorsal sub-lateral nerve cords. (D) Dorsal view of defasciculated DNC in vab-7(e1562) mutant (arrowheads). (E) Ectopic expression of VAB-7 in weIs10 restores normal fasiculation to the DNC in a vab-7(e1562) mutant. (F) Expression of unc-129::gfp in vab-7(e1562), showing normal fasiculation of DA and DB neurones in the VNC. Anterior is towards the left. Scale bars: in A, 15 µm in A-C,E,F.
