Fig. 2. Mutations in cic cause the development of ectopic veins. (A,B) Wild-type and cic²/bwk¹¹ (C,D) adult wings showing the L2-L5 longitudinal veins. (B,D) Show a close view of the region corresponding to the L5 tip. Note the presence of cells showing different degrees of pigmentation, and bearing hairs of different length and thickness in D (small arrows). (E,F,H) Adult wing containing two cic² M⁺ homozygous clones marked with the forked hair marker. (F) Close view of the anterior ventral clone shown in E, showing that cic mutant cells can differentiate either as ectopic vein tissue (white arrowhead) or as intervein tissue (black arrowhead). Note also a patch of cells outside the clone that differentiate as an ectopic vein (small arrow). (H) Close view of the wild-type dorsal surface opposite the ventral clone shown in F, displaying patches of ectopic veins (small arrows). (G) Adult wing containing a dorsal and ventral cic² M⁺ clone occupying all the anterior compartment. In this mosaic wing, all the region between the margin and the L3 differentiates as vein tissue, whereas the region between L3 and the AP boundary differentiates as intervein, exactly as in the cic²/bwk¹¹ mutants.

Return to article