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Fig. 4. BDNF induces granule cells to initiate migration. (A) The same proportion of wild-type (124 of 1163 control; 144 of 1720 with added BDNF) and Bdnf–/– (103 of 1195 control; 69 of 823 with added BDNF) attached in the absence or presence of exogenous BDNF. (B) Exogenous BDNF increases the migratory index in cultures of both wild-type (45 of 124 control; 75 of 144 with added BDNF) and Bdnf–/– (25 of 103 control; 36 of 69 with added BDNF) cells, restoring migration of mutant cells to wild-type levels. **P<0.01 and ***P<0.0002 by {chi}2 analysis. (C) BDNF does not affect the speed of granule cell migration. White bars, wild-type animals; black bars, Bdnf–/– littermates.





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