Fig. 2. Segmental expression in the hindbrain has not been affected in kreisler^r3/r5 mice. Wild-type (A-C) and kreisler^r3/r5 embryos (D-F) were analysed for the expression of several marker genes. Whole-mount in situ hybridisation for Hoxb1 revealed its expression in r4 of both wild type (A) and kreisler^r3/r5 embryos (D). Expression of an alkaline phosphatase reporter gene under the control of an r2 enhancer remains confined to r2 in wild-type (B) and transgenic embryos (E). Transcripts of the neuregulin gene can be detected in the dorsal part of the even-numbered rhombomeres and of r1 (C). This pattern of expression is maintained in kreisler^r3/r5 mice (F); the weaker signal is due to the staining having been carried out for less time.

Return to article