Fig. 4. Disruption of fbm neuronal migration in kreisler^r3/r5 embryos. The expression pattern of neuronal markers and location of fbm neurones is shown in dorsal views and sections of embryos after in situ hybridisation or ß-galactosidase staining of lacZ reporter line. (A-D) Dorsal views of Isl1 expression in wild-type embryos at E11.5 (A) and kreisler^r3/r5 embryos at E11.5 (B,C) and E12.5 (D). (E,F) Ret expression detected in coronal (E) and longitudinal (F) sections through hindbrain of E12.5 embryos. (G-I) Hoxb1/lacZ reporter gene expression in wild-type (G) and kreisler^r3/r5 (H, dorsal view; I, sagittal longitudinal section) embryos at E12.5. (J-L): Dorsal views of Phox2b expression in wild-type (J) and kreisler^r3/r5 (K,L) embryos at E11.5. The arrows in E,F,I point to the ectopic motor nucleus that protrudes into the hindbrain ventricle.

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