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Fig. 5. Disruption of onset of Isl1 and Phox2b expression in neurones. (A,B) The expression of Isl1 was analysed in wild type (A) and kreislerr3/r5 (B) E10.5 embryos. (C,D) The expression of Phox2b was analysed in wild-type (C) and kreislerr3/r5 (D) E10.5 embryos. Expression of both markers was found to be reduced in r3 and r5 of kreislerr3/r5, indicating that there is a decrease in the number of neurones expressing these markers that have initiated differentiation.





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