Fig. 7. Model for TLP-1 function in the T cell lineage. tlp-1 is asymmetrically expressed and functions in the T cell lineage. LIN-44/Wnt signal emanating from the tail hypodermal cells posterior to the T cell is indicated, as are LIN-17/Fz receptors, which are presumably present on the surface of the T cell. TLP-1 expression is indicated by ‘TLP-1’. Hypodermal (hyp) T.a fate is represented by purple shading, neural (n) T.p fate is represented by green shading. Normal T.apa fate is represented by red shading and T.app fate by blue shading. TLP-1 is expressed in the T, T.p and T.app cells in wild-type animals, and affects the divisions of the T.p and T.ap cells. TLP-1 may not be expressed in T.ap, indicated by TLP-1? In lin-44 animals, TLP-1 expression and T cell polarity are reversed. In lin-17 animals, TLP-1 expression and cell polarity are lost.
