Fig. 5. Modulation of Emx2 expression influences growth capacity of neural stem cells. Growth profiles of (A) Emx2-infected ANSCs, (B) Emx2-overexpressing transgenic ANSCs and (C) Emx2 KO-derived stem cell lines as compared to their wild-type controls. Enforced gene expression always gives rise to severe growth impairment, whereas absence of the gene enhances neural stem cell growth. Logarithmic scale on y-axis. Statistical analysis was performed by means of the Bonferroni test. Means ± s.e.m., n=6 for infected ANSCs, n=4 for gain-of-function ANSCs and n=12 for loss-of-function ANSCs.
