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Fig. 4. FGF signalling upregulates CNP-specific genes and represses neuronal differentiation in vivo. (A) Diagram showing position of bead beneath stage 7+ CNP. (B,C) FGF4 beads placed beneath the CNP maintain ectopic expression of cash4 (B) and Sax1 (C), but control PBS beads (D,E) do not alter gene expression. (F,G) FGF8 beads inhibit expression of NeuroM (F), while PBS beads do not (G). Scale bar: (B-G) 200 µm.





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