Fig. 3. Apc1 is ubiquitously expressed. (A-F) Whole-mount immunostaining of Apc1Q8/Apc1Q8 (A-C) and Apc1Q8/+ (D-F) embryos with an anti-Apc1 sera. Whole embryos (A,D), epidermis (B,E) and gut (C,F) are shown. For each paired set of images, the same confocal microscope settings have been used. Although Apc1 staining is most prominent in the nervous system, there is a low, but consistent increase in the intensity of staining for Apc1 in all cells in Apc1Q8 heterozygous embryos when compared with their homozygous Apc1Q8 mutant siblings.
