Fig. 2. HNF1ß liver-specific mutation results in a severe growth defect and in accumulation of bile components in serum. (A) Picture of 2-month-old control and mutant littermates. (B) Growth curves of a litter resulting from a Hnf1ßflox/flox x Hnf1ßlacZ/+AlfpCre cross. Weight was measured from day 15 after birth. Black squares, control (CO) males (mean of four mice); black circles, control females (mean of five mice); white squares, mutant (M) males (mean of three mice); white circles: a mutant female. Standard deviation for each sample is featured as error bars. (C,D) Biochemical analysis of bilirubin (C) and bile acids (D) levels in mutant (black bars) and control (gray bars) mice. Values are mean of 3-4 mice. All differences between mutant and controls were significant (P<0.05). Standard deviations for each sample are indicted by as error bars.
