Fig. 5. Ptc-signaling during head morphogenesis. Pharate adults are shown. (A) Hs-hh individual. (B) The head capsule defect in smo/+ pharate adult with smo– mitotic clones. (C) babo³²/Df (2R) NP1 individual. (D) ptc^H84, +/+, babo³² individual. (E,F) ptc^gal4/Df (2R) NP3; UAS-babo^act individual, ventral and dorsal views. Note that the head capsule defect is completely rescued by the expression of activated Babo in the Ptc-domain from the ptc^gal4 (see text). (G) ptc^hdl/ptc^H84; UAS-babo^act/69B-GAL4, the head capsule defect is also rescued by the expression of activated Babo using a disc-specific driver (see text). (H) The genetic epistatic relationship between hh, ptc, smo and babo during head development. This genetic pathway does not necessarily indicate a linear relationship between Ptc-Smo signaling and Babo signaling, as there are other possibilities that have not been ruled out (see text).

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