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Fig. 9. Model for the dual control of Mos on MPF activation in Xenopus oocytes. Mos associates with Myt1 independently of MAPK cascade activation (broken arrow). This interaction could facilitate Myt1 inactivation by restricting the access of Myt1 phosphatase (PPase) and/or by Myt1 phosphorylation by Mos on some sites. Thus, the Mos/Myt1 interaction could lead to Myt1 inactivation by allowing its complete phosphorylation by other(s) kinase(s) and therefore enhancing MPF activation.





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