Fig. 10. Increased inflammation but normal angiogenesis in the wounds of K5ß1-null mice. F4/80 staining for monocytes/macrophages (brown stain indicated by arrows in A and B) at day 2 post-wounding showed no difference. In 5-day wounds (C-F) there was a clear increase in neutrophil presence (as detected by staining for Ly-6G – brown stain indicated by arrows in C,D) in the wounds of K5ß1-null mice (D) compared with control littermates (C). No difference was observed in angiogenesis as detected by staining for PECAM1 – magenta stain indicated by arrows in E,F). Es, eschar; F, fatty tissue; G, granulation tissue; HE, hyperproliferative epithelium; HF, hair follicle. Scale bars: 200 µm in A-D; 40 µm in E,F.
