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Fig. 4. Jun regulates the viability of notochordal cells. (A-D) Histology of sagittal sections of human Col2a1;Jun{Delta}/{Delta} (B,D) and Junf/f control foetuses (A,C) at E13.5 (A,B) and E14.5 (C,D). Arrowheads in D indicate the nucleus pulposus; nc, notochord; pv, prevertebrae; im, intervertebral mesenchyme; vc, vertebral cartilage; np, nucleus pulposus. (E,F) Cell proliferation measured by BrdU incorporation in E13.5 Col2a1;Jun{Delta}/{Delta} (F) and Junf/f control foetuses (E). (G,H) Apoptotic cell death measured by TUNEL staining (green) in E13.5 Col2a1;Jun{Delta}/{Delta} (G) and Junf/f control foetuses (H). Sections were counterstained with propidium iodide (red). Arrows indicate TUNEL-positive cells.





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