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Netrin, cell repulsion and myelination

Spinal cord myelination crucially depends on the long-distance migration of oligodendrocyte precursors (OPs) that originate from a ventral ventricular zone (VVZ) domain in the developing neural tube. Tsai et al. now report that the initial dispersal of OPs from this location is mediated by a chemorepulsive response to netrin 1, which belongs to the well-known family of neuronal chemorepellants and chemoattractants. They show, on p. 2095, that netrin 1 is expressed in chick ventral spinal cord when OPs initially migrate from the VVZ. In vitro, both chick ventral spinal cord explants and netrin 1-positive cells repel migratory OPs, which express the netrin 1 receptors DCC and UNC5. This chemorepulsive response can be inhibited by a function-blocking, anti-DCC antibody. These, and other, findings reported here highlight the crucial role of netrin 1 in the process of axon myelination.

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Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal

Hui-Hsin Tsai, Marc Tessier-Lavigne, and Robert H. Miller
Development 2003 130: 2095-2105. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?