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New role for Tbx3 in the yolk sac

To investigate the role of the T-box gene Tbx3 in the human developmental disorder ulnar-mammary syndrome (UMS), which is caused by spontaneous mutations in TBX3, Virginia Papaioannou and colleagues created Tbx3-knockout mice. They report, on p. 2263, that although heterozygous mutant mice have only a mild developmental phenotype – UMS is a dominant disorder – the homozygous mutants recapitulate two of the main features of the disorder: abnormal forelimb and mammary gland development. Moreover, massive cell death of the yolk sac endoderm occurs in Tbx3-null embryos at various times in midgestation. Subsequently, and possibly as a result, mutant embryos die over several days, with none surviving to birth. These mutant mice therefore reveal a novel role for Tbx3 in the yolk sac and provide a means for investigating the role of this gene in limb and mammary gland development.

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Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

Todd G. Davenport, Loydie A. Jerome-Majewska, and Virginia E. Papaioannou
Development 2003 130: 2263-2273. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?