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Fig. 4. The RAR{alpha}-selective (BMS753) and the RAR{gamma}-selective (BMS961) agonists, induce ectopic expression of the Rare-hsp68-lacZ transgene in the frontonasal mass and tail, respectively, without altering branchial arch development. Ventral views (A,D,G) of wild-type embryos, and details of their pharyngeal (B,E,H) and caudal (C,F,I) regions, after 48 hours in culture either without retinoid (vehicle) or in the presence of isotype-selective RAR agonists. B1 and B2, branchial arches 1 and 2, respectively; F, frontonasal process; H, heart. Arrowheads indicate the first branchial cleft and red arrows point to the tips of the tails.





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