Fig. 1. The structure and ultrastructure of adult zebrafish head kidney. (A) The zebrafish head kidney is located in the anterior part of kidney. (B) In situ hybridization of scc, which identifies the interrenal gland of the head kidney (arrows, ventral view). Asterisks indicate pigment. (C) Higher magnification of the interrenal gland of the right lobe. (D) A section of the gland. (E,F) Higher magnification of the boxed regions in G and D, respectively. (G) Interrenal epithelial cells (arrows) lie adjacent to a blood vessel (asterisks). rt, renal tube. (H) Transmission electron micrographs showing interrenal epithelial cells (i) associated with adrenaline (a) and noradrenaline (n) chromaffin cells. (I) The interrenal epithelial cell has many mitochondria (m). Nu, nucleus. (J) The adrenaline cell (a) contains electron-lucent vesicles and the noradrenaline cell (n) contains vesicles with strong electron-dense granules. Scale bars; 10 µm (C,D,G), 5 µm (E,F), 1.1 µm (H), 0.6 µm (I), and 0.4 µm (J).

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