Fig. 3. The structure of SPR-3 from C. elegans and C. briggsae. (A) The determined structure of C. elegans SPR-3 and the 3' end of the C. briggsae homolog. Black boxes indicate the location of the predicted C₂H₂ zinc fingers and gray boxes indicate the locations of sequences that might act as nuclear localization signals. In the region confirmed, the structure of the C. elegans and C. briggsae transcripts are very similar. (B) An alignment of the C. elegans and partial C. briggsae sequences of SPR-3. Also shown is a region 5' of the determined sequence of the C. briggsae SPR-3 that is similar to the zinc fingers 1 and 2 of the C. elegans spr-3 gene, and is predicted to be part of the C. briggsae spr-3 gene. Identical amino acids are highlighted in black and similar amino acids are indicated in gray. Predicted zinc fingers are underlined and regions containing sequences that could act as nuclear localization signals are boxed. The positions of point mutations are shown with an asterisk. (C) Alignment of the zinc-finger regions of SPR-3 with REST (Homo sapiens). Identical amino acids are highlighted in black and similar in gray. Gaps in the alignment are indicated by hyphens and gaps between segments of SPR-3 are indicated by blank spaces.

Return to article