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Fig. 8. Xgly4 inhibition of elongation is rescued by the activation of the
non-canonical, but not the canonical, Wnt pathway. It has previously been
shown that Xdsh
DIX cannot activate the canonical Wnt pathway, whereas
DEP cannot activate the non-canonical pathway. Inhibition of
activin-induced elongation (top left) by Xgly4Mo (41 ng; top right) was
rescued by DIX (50 pg; middle right) but not by DEP (50 pg;
middle left), which suggests that Xgly4 regulates the convergent extension
movements by acting as a positive modulator of the non-canonical Wnt pathway
upstream of Dsh. When injected alone, DEP (bottom left) and DIX
(bottom right) had no effect.
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