Fig. 7. Impairments of the eyes of bcox morphants. (A,D) pax6.1 expression at 30 hpf in wild-type embryos, (B,E) bcox morphants and (C,F) citral-treated wild-type embryos (lateral and dorsal views). As indicated by arrows, pax6.1 expression is particularly reduced in the ventral retina of bcox morphants and citral-treated wild-type embryos. (G,H) The pax2.1 expression domain is enlarged in the optic stalk of bcox morphants (H) when compared with controls (G). (I,J) shh expression is not altered in bcox morphants (J) when compared with controls (I). (K,L) Cross-sections through the eyes of bcox morphants (L) and control siblings (K) at the same magnification. (K',L') The insets show a higher magnification of the outer layers of the retina. Note the shortened and less stratified outer segments of the photoreceptors in bcox morphants (L'). (M) Retinoid composition of the eyes of 4 dpf larvae of wild type (upper trace) when compared with bcox morphants (lower trace). The figure shows the profiles at 360 nm of extracts isolated from 80 eyes per trace and separated on HPLC system 1.

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