Fig. 5. Morphology of ovulated COCs in mice with different Tnfip6 genotypes. Females of all three Tnfip6 genotypes are able to ovulate as indicated by the presence of oocytes within the oviduct (A-C). The dense cloud-like material (black arrowheads) around the oocytes in the oviducts of wild-type and Tnfip6^+/– females are the expanded cumulus layer. Oocytes in the oviduct of the Tnfip6^–/– females lack the same dense material (C, white arrowheads). This difference is clearly seen when isolated COCs are compared (D-F). COCs from wild-type and heterozygous females show normal morphology, while oocytes from the homozygotes do not have a cumulus layer. These latter oocytes are either completely nude (not shown) or they are associated with a dispersed network of granulosa/cumulus cells (F). Scale bars: 100 µm.

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