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Fig. 5. Absence of cortical hem patterning defects in Wnt1-Tg mice. Hematoxylin and Eosin staining of control littermates (A,B) and Wnt1-Tg mice (E,F) at 12.5 dpc showed only mild disorganization of the cortical ventricular zone and cortical hem. Poor definition of the choroid plexus primordium from the surrounding thalamic eminence was noted. Expression of the cortical hem marker Wnt2b (D,H) and the roofplate organizer marker Bmp4 (C,G) were normal in Wnt1-Tg mice by in situ hybridization at 12.5 dpc. cpp, choroid plexus primordium; hem, cortical hem; cp, cortical ventricular zone; di, diencephalon. The bracket delineates the cortical hem region. All sections are coronal.





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