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Fig. 5. Absence of cortical hem patterning defects in Wnt1-Tg mice.
Hematoxylin and Eosin staining of control littermates (A,B) and
Wnt1-Tg mice (E,F) at 12.5 dpc showed only mild disorganization of
the cortical ventricular zone and cortical hem. Poor definition of the choroid
plexus primordium from the surrounding thalamic eminence was noted. Expression
of the cortical hem marker Wnt2b (D,H) and the roofplate organizer
marker Bmp4 (C,G) were normal in Wnt1-Tg mice by in situ
hybridization at 12.5 dpc. cpp, choroid plexus primordium; hem, cortical hem;
cp, cortical ventricular zone; di, diencephalon. The bracket delineates the
cortical hem region. All sections are coronal.