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Fearing coalescence in gonad development

Two types of cellular movement underlie proper gonad formation in animals: individual cell migration, where primordial germ cells migrate from their site of origin to contact the cells of the somatic gonad; and coordinated tissue morphogenesis, where germ cells and somatic cells coalesce to form the embryonic gonad. Now Ruth Lehman and colleagues shed light on these little understood events with their phenotypic and molecular characterization of the fear of intimacy (foi) gene in Drosophila (see p. 2355). foi is required for gonad coalescence, but not for somatic gonad or germ cell identity. Its protein, which is predicted to belong to a novel family of conserved transmembrane proteins and is required in gonadal mesoderm for coalescence to occur, localises to the cell surface, where the authors propose that it might cooperate with E-cadherin in this morphogenetic process.

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fear of intimacy encodes a novel transmembrane protein required for gonad morphogenesis in Drosophila

Mark Van Doren, Wendy R. Mathews, Monique Samuels, Lisa A. Moore, Heather Tarczy Broihier, and Ruth Lehmann
Development 2003 130: 2355-2364. [Abstract] [Full Text]  

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content